During the 300th episode of Grey’s Anatomy, Meredith (Ellen Pompeo) and everyone else at Seattle Grace Hospital were stunned by patients Greg and Cleo. It started everyone down a road of memories, which had audiences in tears.
They looked just like George (T.R. Knight) and Christina (Sandra Oh), who haven’t been on the show in years.
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Incredibly, the two โ who are stuck inside a roller coaster car โ are both interns at Seattle Presbyterian! They are also big fans of Dr. Grey. Their friend, the pregnant woman Liza, also looks curiously like Izzie (Katherine Heigl).
Meredith was supposed to fly off for the Harper Avery awards ceremony, but she stayed around to help the patients. Even though she wasn’t there, she still won. She could see the ghost of her mom, Ellis Grey (Kate Burton), observing her moment.
Before the show, the crew behind Grey’s told fans that they would be seeing “ghosts” during the episode. Indeed, there was a lot of reminiscing going on among the doctors.
“Episode 300 is going down kind of like memory lane. We’ll see some actors who come into the hospital after a horrific accident who remind us of Izzie and George and Cristina Yang,” James Pickens Jr. told E! News.
“And it’s so cool how they do it. And they found three remarkable actors…When I came and I saw them, I said, ‘Wow,’ because they were such integral parts of the success of the show and such amazing talents in their own rights, so we miss them very much. So it will be nice for the audience to say, ‘Oh wow, there they are.’”
Here’s how fans reacted to the episode on Twitter.
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Debbie Allen, who directed the episode, toldย E! Newsย that fans should keep their eyes open for surprises. However, no one returned for the show, other than Burton.
Alex omg my heart #Greys300 pic.twitter.com/uIHKuSe7fu
โ kate? (@avengerhes_) November 10, 2017
“There’s a lot of little nuggets and throwbacks to the past,” Allen said. “I call it our Hubble telescope episode, because the Hubble telescope lets you look back into the past and forward. And this show, it’s all of that.”
i can’t stop crying. #Greys300
โ sydney โ (@sydneyyydoll) November 10, 2017
Oh my god best episode ever @GreysABC #Greys300
โ Amanda (@_amanduhplease) November 10, 2017
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Kevinย McKidd, who plays Owen, toldย Entertainment Tonightย that he hoped Sandra Oh would return.
I๏ธ miss Cristina Yang so hard it hurts #Greys300
โ Abbegail (@AbbegailVaughn) November 10, 2017
“I hope she will. I think it would be so much fun,”ย McKiddย added. “It would open up so much again in the story and mix everything up. Owen, wherever he is in his life, would have incredible stories. She’s just such an amazing actor. I still miss her to this day.”
“There’s no one like Cristina, no one.”- Owen ?? #Greys300 #GreysAnatomy
โ Natalia(; (@nataliaa786) November 10, 2017
In the end of the episode, Owen refused to agree that Cleo looked like Christina. Oh didn’t physically return, but she did call Meredith to congratulate her.
that picture of cristina of meredithโs phone though … ??? #Greys300 pic.twitter.com/MlmpmaFyrD
โ Hilarie Malamed (@justhilray) November 10, 2017
Cristina only called Meredith to ask how she won the Harper Avery while still being at Grey-Sloane, when she was told she could never #Greys300 #GreysAnatomy pic.twitter.com/eoNyG1iBv7
โ Mal (@MalloryAK2019) November 10, 2017
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Fans loved hearingย Alex imagine Izzie’s life since Katherine Heigl leftย Grey’s.ย
The music. The Harper Avery. The nod to baby interns. George, Izzie, Cristina. Derek saving lives. The sad realization that it’s just Meredith & Alex. 300 episodes gone. All the feels. #Greys300 #GreysAnatomy
โ Mirela (@mir_ela_) November 10, 2017
ALEX TALKING ABOUT IZZIE LIKE THAT IS NOT SOMETHING I NEEDED DAMN IT ???#Greys300 #GreysAnatomy pic.twitter.com/O4CQSajXau
โ Daughter of DemPeo (@dempeogreyshep) November 10, 2017
You can tell Alex still loves Izzie alot #Greys300
โ Austin (@AustinKeith_626) November 10, 2017
โI picture her as happy as I am with you.โ Alexโs imagined life for Izzie is actually really sweet (but the whole doppelgรคnger angle was oddly played out, tbh). #Greys300
โ christina (@varietyofwords) November 10, 2017
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Some fans were disappointed that Christina and other characters didn’t actually return to the show. Instead, the hour was littered with references.
References were not enough for these fans.ย
I deserve to see someone return in this episode. References arenโt enough! I want Cristina to be there when Meredith wins. #Greys300.
โ frauds.โ (@caucasiandoves) November 10, 2017
Disappointed Cristina did not return for #Greys300 ugh Iโd do anything. My favorite tv character of all time.
โ Jake Bodell (@JakeBodez) November 10, 2017
Hi Katie, will you be watching the #Greys300 tonight? Hopefully one day we will see Izzie Stevens return for a visit?
โ JMO Fan For Life? (@AspireWriter21) November 9, 2017
Would’ve been nice 2 see Callie & Sofia return for the ep aswell & show that Callie & Arizona r friends @GreysABC @SaraRamirez #Greys300
โ Kath_Clarke01 (@KClarke01) November 6, 2017
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Most fans were just excited to see Meredith finally win her overdue Avery award.ย
Maybe we can also convince @IamSandraOh to come back for a cameo to accept her long overdue Harper Avery?? ? #Greys300 #GreysAnatomy
โ The C.E.O. (@syd_tha_kid93) November 10, 2017
Y’all cried too when Meredith won the Harper Avery, right? Asking for a friend…#GreysAnatomy #Greys300
โ m_alyse_tx (@marisa176) November 10, 2017
She puts the GREY in #GreysAnantomy so Mer winning the Haper Avery made perfect sense for #greys300 I couldn’t be happier and prouder! ???? #girlpower @EllenPompeo
โ Nicole McDoom (@NicoleMcDoom) November 10, 2017
@GreysABC Thanks you’re making me blush like I won the Harper Avery #greys300 @EllenPompeo @KristaVernoff @shondarhimes https://t.co/ZNypPf5Grx
โ Nicole (@steadystateCSTR) November 10, 2017
#Greys300 WE HAVE TO SEE SOMETHING FROM CRISTINA HER PERSON JUST WON A HARPER AVERY !!!!! im crying ????????
โ |Kristen| (@bellaxkristen) November 10, 2017